John Campbell, captain of Jamaica Scorpions, believes the wicket of Barbados Pride opener Kraigg Brathwaite will be key if the Jamaica Scorpions is to make a comeback in their WICB Professional League encounter at Sabina Park.Brathwaite, the captain of the Pride, at the close was on 66 when his team closed on 103 for three on the first day.This was in reply to the Scorpions pedestrian first-innings total of 177 after they had won the toss and elected to bat.”His (Brathwaite’s) wicket will be key, and if we can come out and get his wicket, I think their batting will be under some pressure,” stated Campbell, who is leading the Scorpions for the second time.Coming off scores of 117, 30 and 34 since his return from Australia with the West Indies Test team, Brathwaite, in his usual accumulating style, has so far batted for close to two and, half hours and hit 11 fours.Of note, as well, was his duel with the tournament’s leading wicket-taker, left-arm spinner Nikita Miller.Closing with competitive figures of three for 22 off 14 overs, Miller got the ball to turn considerably, putting Brathwaite and others under pressure at times.”Miller put in a good spell,” conceded Brathwaite, who is eyeing a 16th first class in the process.”Once the spinners hit in the right areas, it is not easy scoring as the pitch is turning.”But its’ just about trusting my defence and staying positive when I see the ball to score and rotation of the strike.He continued: “I would like to score a hundred here at Sabina Park. The last couple of times, I scored two 90s.”I am working towards that, but, at the end of the day, I am looking to build a foundation with my team to get a big score.”With him at the close was the in-form Royston Chase, who has batted for 39 minutes and is nine not out.Earlier, the Jamaica Scorpions, hoping to break a string of three consecutive defeats, were led to their total by Andre McCarthy, 52, and opener Shacaya Thomas, 50.McCarthy, entering the fray with Jamaica at 42 for one, batted for one hour and 48 minutes and counted six fours and a six, while Thomas batted for an hour and 34 minutes on his way to hitting his second half century in as many matches.Former West Indies Under-19 fast bowler Justin Greaves with five for 41, his first five-wicket-haul in his third first-class encounter, was the pick of the bowlers.New West Indies left-arm spinning recruit Jomel Warrican ended with two for 43.”We did not get anywhere close to the runs that we wanted,” Campbell highlighted.”But, having said that, the total is already there and is a task for our bowlers to go and defend.”
4 Keys to a Kid-Safe App Tags:#Downton Abbey#streaming#video Except that this isn’t really about monetization. They’re giving the show away free to PBS viewers. They’re just making us wait six months to get it.Six months… of all those Brits gleefully filling Facebook and Twitter with talk of Mary’s baby, Lord Grantham, etc. I’m not going to wait. Neither is Laura Stampler of Time. Or a host of mommy blogs (here and here).Can’t Wait? You Needn’tI’ll let the blogs above tell you how to set up a VPN to spoof a U.K. IP address. Or you can simply use Get iPlayer Automator to download the video files each week after the program airs in the U.K. No, you won’t be watching it live, and you’ll have to watch it on your computer unless you move the show to your tablet or phone. You could also use your TV if you’re using AppleTV, Roku or something similar.But you’ll be watching it. And perhaps you’ll then discover all those other BBC and ITV shows friends have raved about.The irony is that I have bought every season, even after watching it before the rest of my American friends. It’s not about getting the show for free. It’s about getting it when my friends in the U.K. do. Given the special relationship that supposedly exists between the two countries, it seems it’s the least ITV could do to make Downton Abbey available to me without stooping to such dastardly tactics.Alas! No. So I’ll download it now, watch it now, and pay for it the second they let me. 5 Outdoor Activities for Beating Office Burnout Related Posts So you’re a Downton Abbey addict. I can understand. I am, too. Given that Season 4 just premiered to 9.5 million U.K. viewers, you have two options. One of them will make you immensely happy but an evil criminal. The other will make you a sanctimonious, law-abiding citizen who will be Downton Abbey-free until January 2014.I know which one I’m choosing.There are ways—some easy, some hard—to watch British broadcasts from the U.S., but the real question is why we’re being made to wait at all.Yes, I’m A CriminalIf you live in the U.K. and pay your TV tax, you can watch ITV and BBC programming for free. If you live in the U.S., you can watch many of the same programs for free, but on a time-delayed basis. In the case of Downton Abbey, millions of Britons happily watched it last week. Millions of Americans arguably would have been happy to pay to watch it with them, but were blocked by broadcast rights and some television exec’s decision as to how best to monetize Downton Abbey. 9 Books That Make Perfect Gifts for Industry Ex… Matt Asay 12 Unique Gifts for the Hard-to-Shop-for People…
MIAMI — Cypriot native Garo Yepremian, the former NFL kicker who helped the Miami Dolphins win consecutive NFL championships but is best remembered for a Super Bowl blooper, died of cancer on Friday at the age of 70.Yepremian’s wife, Maritza, said he died at a hospital in Media, Pennsylvania. His illness was diagnosed in May 2014, she said.Yepremian played from 1966 to 1981 after arriving in the United States at age 22 and kicking in the first NFL game he ever saw.His 37-yard field goal in the second overtime ended the longest game in NFL history, a Dolphins’ playoff victory over Kansas City on Christmas 1971, and he helped Miami win back-to-back NFL titles in 1972-73.But Yepremian’s gaffe in the fourth quarter of the Super Bowl in January 1973 nearly spoiled the Dolphins’ bid to complete a perfect season.With Miami leading the game 14-0 and on the verge of finishing the season with a 17-0 record, the Washington Redskins blocked Yepremian’s field-goal attempt. He picked up the ball and tried to throw it but fumbled, and the Redskins’ Mike Bass ran it 49 yards for a touchdown.“Every airport you go to, people point to you and say, ‘Here’s the guy who screwed up in the Super Bowl,’” Yepremian said in a 2007 interview. “After a while it bothers you. If it was anybody else he would go crazy, but fortunately I’m a happy-go-lucky guy.”Decades later, Pro Football Hall of Fame coach Don Shula was able to laugh as he reminisced about the play — perhaps the weirdest in Super Bowl history.“I thought, ‘Boy, this will be great if Garo kicks this field goal and we go ahead 17-0 in a 17-0 season. What a great way that would be to remember the game,’” Shula said. “And then Garo did what he did, and it’s 14-7 with still a couple of minutes to go. I’m looking for Garo, and I’m ready to kill Garo, and I couldn’t find him. He went down to one end of the bench, and I haven’t seen him since.”Despite Yepremian’s mistake, Miami won that game to complete the NFL’s only perfect season. Yepremian also kicked for the Dolphins when they repeated as champions in 1973. Prematurely bald and only 5-foot-8, the left-legged Yepremian hardly looked like an NFL star.He broke in with the Detroit Lions, who signed him as their first soccer-style kicker when that side-footed kicking style was a novelty. As a rookie in 1966 he broke a league record with six field goals in a game at Minnesota.He joined the Dolphins in 1970, made the Pro Bowl twice with them and led the league in field-goal accuracy three times. He also kicked for the New Orleans Saints and Tampa Bay Buccaneers.Private funeral arrangements are pending. A viewing is planned May 20 in Wynnewood, Pennsylvania.(STEVEN WINE)TweetPinShare0 Shares
Touch Football will be one of 41 sports on offer at the eighth Pan Pacific Masters Games on the Gold Coast in November. The Masters Games will run from Saturday, 3 November through to Sunday, 11 November 2012 with the Touch Football part of the event to be played from Wednesday, 7 November to Saturday, 10 November. 15 divisions will be on offer for the Touch Football part of the event, with four Women’s (30+, 35+, 40+, 45+), seven Men’s (30+, 35+, 40+, 45+, 50+, 55+, 60+) and four Mixed divisions (W30+/M35+, W35+/M40+, W40+/M45+, W45+/M50+). The Pan Pacific Masters Games is a celebration of masters’ sport with both fierce and friendly competition and a jam-packed entertainment program at the Games Village at the end of each day. For more information regarding the Touch Football component at the 2012 Pan Pacific Masters Games, please click on the link below: http://www.mastersgames.com.au/default.asp?PageID=13124Related LinksPan Pacific Games
Man Utd plans to sign EIGHT new playersby Paul Vegas14 days agoSend to a friendShare the loveManchester United have plans to sign EIGHT new players over the next two summer transfer windows.Ole Gunnar Solskjaer’s side have had a woeful start to the season and currently sit 15 points behind leaders Liverpool already after just eight matches.The Telegraph says United are well aware of their need to improve their playing staff and will make a number of signings over the next two summers.One of those incomings could be brought forward to January too amid growing concern that a challenge for Champions League football could already be on the rocks. It is claimed the club believe they are “six players short of challenging for major honours” and the overhaul of players will be led by Solskjaer, who still has the full backing of the club.”Ole is looking at a three-year vision of a squad. It will be an evolution over the coming years,” a source said. “We are at base camp now.” TagsTransfersAbout the authorPaul VegasShare the loveHave your say
09May Rep. Bellino: Governor’s veto threat ‘misguided and without merit’ State Rep. Joe Bellino of Monroe today issued the following statement after Gov. Gretchen Whitmer threatened to veto the House-approved plan that would lower car insurance rates across Michigan:“I’m saddened to learn the governor appears willing to preserve our state’s much-maligned no-fault car insurance system at the expense of Michigan drivers. The governor’s threatened veto of a common-sense bipartisan plan to guarantee lower rates for drivers is misguided and completely without merit.“After the governor expressed her dissatisfaction for the Senate version of the plan, we worked with our Democratic colleagues to ensure lower rates were guaranteed and non-driving factors were addressed. Now the governor is making the bizarre excuse that lower rates aren’t guaranteed. It’s guaranteed.“If the governor vetoes this important reform plan, it should be obvious to everyone that she never had any intention of giving more than 7 million Michigan drivers the rate relief they so desperately deserve.” Categories: Bellino News
Source:https://www.hopkinsmedicine.org/news/newsroom/news-releases/sexual-dysfunction-molecular-markers–johns-hopkins-greenberg-bladder-cancer-institute-awards-aim-to-learn-how-bladder-cancer-affects-women Feb 1 2019The Johns Hopkins Greenberg Bladder Cancer Institute awarded research grants to four projects that focus on understanding how treatment of bladder cancer affects women, why the disease has a less favorable outcome for women than men, and how biology could play a role in offering new targets for cancer therapy. The institute encourages new strategies for combating bladder cancer and rewards those areas of innovative study with grants of $25,000 to $50,000. David McConkey, Ph.D., director of the Greenberg Bladder Cancer Institute, says it was not happenstance that some of the projects selected this year focus on women’s bladder cancer.“Bladder cancer presents different clinical challenges in men and women. It is diagnosed more often in men, but on average, women develop more aggressive disease,” says McConkey. “Identifying the root causes of these discrepancies is a top priority for ongoing research. We also need to optimize our surgical approaches in men and women to ensure that we are obtaining the best possible outcomes. The projects we are funding this year directly address both of these priorities.”The Greenberg Bladder Cancer Institute recently launched a women’s bladder program at the Johns Hopkins Kimmel Cancer Center. Jean Hoffman-Censits, M.D., and Armine Smith, M.D., will lead the program.Two of the projects awarded research grants are looking at how bladder cancer treatment impacts the sexual health of women and how women are counseled after undergoing radical cystectomy, a surgical procedure during which the bladder and, typically, the uterus, ovaries and part of the vagina, are removed.Natasha Gupta, M.D., is a resident at the Brady Urological Institute at the Johns Hopkins University School of Medicine. Her project aims to examine the components of sexual health and dysfunction among women with bladder cancer who undergo radical cystectomy, as well as the counseling patients receive regarding these issues.“I am grateful for the resources and support provided by the Greenberg Bladder Cancer Institute,” says Gupta. “They have allowed me to design and conduct studies to understand the important but poorly understood topic of sexual health and dysfunction among women with bladder cancer.”Gupta and her team will also study national practice patterns among urologists regarding radical cystectomy in women and counseling about sexual dysfunction. They are conducting in-depth interviews with patients and their partners about these issues.Gupta hopes a better understanding of sexual health and dysfunction in women with bladder cancer will lead to improved decision making about treatment and better management of sexual dysfunction in patients who undergo radical cystectomy for bladder cancer.Sima Porten, M.D., M.P.H., is a member of the urologic oncology team at the Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco. Sumeet Bhanvadia, M.D., is an assistant professor of clinical urology at the Keck School of Medicine at the University of Southern California. The two want to do an in-depth assessment of sexual outcomes among women after radial cystectomy to understand the extent of sexual dysfunction and its impact on patients and their partners.Related StoriesNew study to ease plight of patients with advanced cancerResearch sheds light on sun-induced DNA damage and repairStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessary“We are honored to have received this award from the Johns Hopkins Greenberg Bladder Cancer Institute,” Porten says. “We believe this will help us address an unmet need and improve the care for women with bladder cancer.”Their pilot study hopes to generate data to develop a quantitative measure of degrees of sexual dysfunction and quality of life issues among women with bladder cancer. This information can be used to develop alternative treatment plans and properly prepare patients for what they may experience after radical cystectomy.Margaret Knowles, Ph.D., at the University of Leeds, and Benjamin Hopkins, a Ph.D. student at Leeds, have identified biological differences between cultured normal cells from the bladders of men and women.“Such differences may have a major influence on the process of tumor development,” Knowles says. “This award will allow us to examine normal cells directly isolated from the bladders of normal males and females to determine whether such differences also exist within the body.”While acknowledging that different exposure risks have been highlighted, Knowles and her team suggest a complete explanation for the gender-related differences in bladder tumor behavior relates to genetic and epigenetic distinctions in these tumors, and such differences may develop because of inherent differences in the biology of the normal male and female bladder.Their goal is to make it possible for treatments to target the specific biology of tumors, taking into account any gender-related differences.Jenny Southgate, Ph.D., director of the Jack Birch Unit for Molecular Carcinogenesis at the University of York, and Simon Baker, Ph.D., deputy director of the Jack Birch Unit, are examining how the skin layers inside the bladder—known as urothelial cells—develop and how those cells have genetic qualities seen in some subsets of bladder cancer.“We are absolutely delighted to have been awarded the grant from the Johns Hopkins Greenberg Bladder Cancer Institute. It is a particularly exciting time for bladder cancer research, with the international surge of interest in this long ignored but important cancer and with much recent progress in establishing different disease subgroups,” Southgate says. “From our particular perspective of normal bladder biology, our study aims to explain the different ways bladder cells use their genes when exposed to different stimulations in the laboratory, which will offer new targets for cancer therapy.”Southgate and Baker will look at receptors in the urothelial cells—turning them on and off—to discover what role they may have in tumor development. They believe their work will provide new insights into bladder cancer subtypes and a new understanding of urothelial biology. Top Left to Right: Natasha Gupta, M.D., Brady Urological Institute, Sima Porten, M.D., M.P.H., University of California, San Francisco, Sumeet Bhanvadia, M.D., University of Southern California. Bottom Left to Right: Margarget Knowles, Ph.D., University of Leeds, Jenny Southgate, Ph.D., & Simon Baker, Ph.D.,University of York
Source:https://healthsciences.ku.dk/newsfaculty-news/2019/03/new-proof-that-narcolepsy-is-an-autoimmune-disease/ Reviewed by Kate Anderton, B.Sc. (Editor)Mar 15 2019Researchers from the University of Copenhagen have discovered autoreactive cells in persons suffering from narcolepsy. This is a new, important proof that the sleep disorder is an autoimmune disease. This knowledge may lead to better treatment of the chronic condition, the researchers behind the new discovery believe.For many years, scientists have expected the sleep disorder narcolepsy of being an autoimmune disease, though without being able to prove it conclusively. Now researchers from the Faculty of Health and Medical Sciences at the University of Copenhagen together with the Technical University of Denmark and Rigshospitalet have found a new, important proof that their presumptions were correct. The new research results have been published in the scientific journal Nature Communications.’We have found autoreactive cytotoxic CD8 T cells in the blood of narcolepsy patients. That is, the cells recognise the neurons that produce hypocretin which regulates a person’s waking state. It does not prove that they are the ones that killed the neurons, but it is an important step forward. Now we know what the cells are after,’ says Associate Professor Birgitte Rahbek Kornum from the Department of Neuroscience.The immune system is designed to recognise viruses and bacteria. When its cells are autoreactive – which is the case in autoimmune diseases – the immune system recognises the body’s own cells and attacks them. That they are cytotoxic means that they are capable of killing other cells. In most narcolepsy patients, the neurons that produce hypocretin and thus regulate our waking state have been destroyed.’To kill other cells, e.g. neurons producing hypocretin, CD4 and CD8 T cells usually have to work together. In 2018, scientists discovered autoreactive CD4 T cells in narcolepsy patients. This was really the first proof that narcolepsy is in fact an autoimmune disease. Now we have provided more, important proof: that CD8 T cells are autoreactive too,’ says Birgitte Rahbek Kornum.Related StoriesMore than 936 million people have sleep apnea, ResMed-led analysis revealsSleep quality and fatigue among women with premature ovarian insufficiencySleep disorders in patients with low back pain linked to increased healthcare visits, costsAutoreactive Cells Were Also Found in Healthy IndividualsIn the study, the researchers studied and analysed blood samples from 20 persons with narcolepsy. In addition, they analysed blood samples from a control group of 52 healthy persons. In nearly all 20 narcolepsy patients the researchers found autoreactive CD8 T cells. But autoreactivity was not only found in persons suffering from the sleep disorder. The researchers also discovered autoreactive cells in a lot of the healthy individuals.’We also found autoreactive cells in some of the healthy individuals, but here the cells probably have not been activated. It is something we see more and more often with autoimmunity – that it lies dormant in all of us, but is not activated in everyone. The next big puzzle is learning what activates them’, says Birgitte Rahbek Kornum.According to Birgitte Rahbek Kornum, the discovery of autoreactive cells in healthy individuals also stresses the theory that something has to trigger narcolepsy and activate autoreactivity. Scientists still do not know what causes the disease. They expect a combination of genetics, autoreactive cells and a form of trigger to bring about the disease, e.g. a virus infection. The disease can be treated medically today, but the new research results may pave the way for even better treatments.’Now there will probably be more focus on trying to treat narcolepsy with drugs allaying the immune system. This has already been attempted, though, because the hypothesis that it is an autoimmune disease has existed for many years. But now that we know that it is T cell-driven, we can begin to target and make immune treatments even more effective and precise,’ says Birgitte Rahbek Kornum.
This March 19, 2018, file photo shows the Netflix app on an iPad in Baltimore. Netflix reports financial results Tuesday, April 16, 2019. (AP Photo/Patrick Semansky, File) Netflix shares jump 6 percent on strong subscriber growth The ground-breaking video service added 9.6 million subscribers worldwide during the opening three months of the year, topping the projections of both Netflix’s own management and the analysts that steer investors’ expectations. The first-quarter surge left Netflix with nearly 149 million subscribers through March.Netflix’s performance may help ease any worries related to a recent price hike that raised the cost of its most popular plan to $13 a month, a $2 increase. New U.S. subscribers had to start paying the higher price in January, but it only recently started to hit existing customers. Citation: Netflix adds 9.6M subscribers in 1Q as competition heats up (2019, April 16) retrieved 17 July 2019 from https://phys.org/news/2019-04-netflix-96m-subscribers-1q-competition.html Netflix’s popularity is still booming, even as the video streaming service rolls out it biggest U.S. price increases and girds for new challenges from Walt Disney and Apple, two of the world’s most popular brands. © 2019 The Associated Press. All rights reserved. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.